The Scope of the Problem
COPD is involved in up to 20% of hospitalizations for adults in the U.S.
While there are studies that aid in evaluation, an acute COPD exacerbation is a clinical diagnosis that is characterized by symptoms which are more severe than the patient’s baseline. This includes, among other symptoms, worsening dyspnea, increased cough and sputum production, worsening wheezing, and increased oxygen requirements.
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines note that COPD is the third leading cause of death in the United States.
Who is Safe for Discharge?
The GOLD guidelines recommend admission for these patients:
- Those significantly worsened from their baseline
- Patients with a poor response to ED management of their symptoms
- Patients with significant comorbidities
- Those with worsening hypoxia or hypercarbia
- Those who will be unable to cope at home
The DECAF score has been validated and found to outperform other commonly-used stratifying scores such as CURB-65 or APACHE to identify patients at risk of in-hospital or 30-day mortality
A score of 3 or greater is associated with an in-hospital mortality rate of 15%, which rises with increasing DECAF score. Inpatient management is recommended for these patients.
Should these patients be given antibiotics?
There is evidence of benefit for patients who are admitted, but this is less clear for patients with milder exacerbations who are treated as outpatients.
How do we predict FEV1 at the bedside?
This can be difficult – assessing peak flow is a substitute but is highly dependent on the patient’s effort. A patient with a peak flow of 70% of expected or greater is likely safe for discharge. This presumes there are no other indications for admission.
To sum up…
Patients presenting with acute COPD exacerbation who meet the following criteria may be appropriate for outpatient management:
- No or only mild increase in dyspnea from baseline
- Minimal increase in baseline hypoxia or hypercarbia
- Comorbid conditions are well-controlled and do not complicate the acute clinical picture
- Able to fill prescriptions and care for self at home
- DECAF score less than 3