Some Definitions
Pyelonephritis is a subset of urinary tract infection, and needs to be differentiated from cystitis, which is infection confined to the urinary bladder. Pyelonephritis is an infection involved the renal parenchyma and collecting system and is characterized by a clinical picture of urinary tract infection, fever, and flank pain.
Historically, patients with pyelonephritis were routinely admitted for inpatient management, but more recent literature suggests many of these patients can safely be managed as an outpatient. Which raises the question, which pyelonephritis patients can safely be sent home?
First, we’ll deal with the easy stuff…
Special Populations
Some patients should be admitted for inpatient management of pyelonephritis, with very few (or no) exceptions. These are
- Pregnant patients – studies have shown these women develop anemia, sepsis at higher rates than non-pregnant patients, and they are at higher risk for pre-term labor
- Renal transplant patients
- Immunocompromised patients – especially those on immunosuppressive medications. Patients with impaired immune response due to chronic illnesses such as liver disease, diabetes mellitus, sickle cell disease, and others should be considered higher risk and typically require admission.
For Everyone Else
Some clinical factors that should prompt you to admit for inpatient management include:
- Persistently abnormal vital signs
- Toxic appearance
- Inability to tolerate oral intake
- Signs of urinary obstruction
- Suspicion that the patient will be unable to adhere to outpatient treatment
Safe for Home
So, who can go home? First, it’s important to understand that most patients who present with pyelonephritis will complain of pain, be febrile, and will likely be tachycardia on arrival. If you can improve or resolve these abnormalities while they’re in the ED, you may be able to send them home.
Some studies even show that patients with pyelonephritis who are still febrile at discharge tend to do well if they don’t have other complicating factors.
In general, patients appropriate for outpatient management can fulfill these criteria:
- Pain is well-controlled
- Able to tolerate oral intake
- Does not appear septic
- No signs of urinary tract obstruction – this is worth special attention, as infected ureteral stones have a high incidence of increased morbidity and mortality
- Not pregnant, not immunocompromised, and without other systemic illness that would complicate outpatient treatment
As a general rule, these patients should receive their first dose of antibiotics in the emergency department prior to discharge and should have a discussion about clear indications to return to the emergency department.